Synthesis and antimicrobial studies of substituted 2-phenylbenzimidazole derivatives.

The substituted 2-phenylbenzimidazole derivatives were synthesized by introducing different substituents at different positions. Six novel benzimidazole derivatives were synthesized successfully in appreciable yields and characterized physicochemically. The structures of all the synthesized derivatives were confirmed by IR and 1HNMR. Furthermore, the synthesized compounds were screened for antimicrobial activity (antibacterial activity and antifungal activity) by tube dilution method. Some of the synthesized compounds showed appreciable antifungal activity.

Synthesis and Antimicrobial studies of novel Benzimidazole derivatives.

Two series of novel benzimidazole derivatives were synthesized. The first one comprise of 2-methyl, the second one comprise of 2-phenyl substitution on benzimidazole moiety. Seven novel benzimidazole derivatives were synthesized successfully in appreciable yields and characterized physicochemically. The structures of all the synthesized derivatives were confirmed by IR and 1HNMR. Furthermore, the synthesized compounds were screened for antimicrobial activity (antibacterial activity and antifungal activity) by tube dilution method. Some of the synthesized compounds showed appreciable antifungal activity.

HER-2 targeted immunonanoparticles for breast cancer chemotherapy.

The success of anti-cancer drug targeting is depends on the ability of the therapeutics to reach their desirable cellular and intracellular sites and minimizing action at the nonspecific sites. In the present study, anti-human epidermal growth factor receptor (HER-2, ErbB2) antibody anchored nanoparticles were prepared and evaluated for the assessment of targeting potential in breast cancer cell. In an attempt for comparison of carrier system for site-selective delivery, docetaxel loaded PLGA nanoparticles, PLGA-PEG nanoparticles and PLGA-PEG immunonanoparticles capable of targeting breast cancer were prepared by emulsion solvent evaporation technique. The drug-loaded nanoparticles were characterized for their size and size distribution, surface charge, drug encapsulation efficiency and in vitro drug release. Our results demonstrate that docetaxel loaded PLGA-PEG immunonanoparticles strongly enhances the site specific uptake and high cytotoxic effect at targeted sites, as compared with PLGA, PLGA-PEG nanoparticles. In conclusion polymeric immunonanoparticles could be a promising carrier for the treatment of HER2-overexpressing breast cancers.